Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about pgc_1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| h-7210c29bb9 | targeted_by | hypothesis | 1.00 |
| h-26b9f3e7 | targeted_by | hypothesis | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-7210c29bb9 | targets | hypothesis | 1.00 |
| h-26b9f3e7 | targets | hypothesis | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resil | 0.778 | neurodegeneration | Gut Microbiome Analysis in Parkinson's D |
| APOE4 drives astrocyte metabolic reprogramming toward glycol | 0.580 | neuroscience | APOE4-driven lipid metabolism dysregulat |
| HBOT at 2.0 ATA for 60 minutes restores PGC-1α-mediated mito | 0.520 | neurodegeneration | What are the optimal oxygen pressure, du |
| Mitochondrial Biogenesis Rescue via PGC-1α Activation | 0.000 | - | Metabolic reprogramming in neurodegenera |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| PGC-1α knockout analysis of PV+ interneuron maturation | validation | neurodevelopmental disorders | 0.850 | 0.00 | knockout mice | proposed | N/A |
| PV+ interneuron subtype diversification analysis | exploratory | neurodevelopmental disorders | 0.750 | 0.00 | mouse cortical PV+ interneuron | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning pgc_1 in their description or question text
No additional research found