Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about pi3k-akt-signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
The PI3K/AKT signaling pathway is a critical pro-survival cascade that regulates neuronal survival, metabolism, synaptic plasticity, and protein homeostasis[@brazil2024]. Dysregulation of this pathway significantly contributes to neuronal death in Alzheimer's disease (AD), Parkinson's disease (PD),
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| Name | pi3k-akt-signaling |
Knowledge base pages for this entity
graph TD
A["Upstream trigger"] --> B["pi3k akt signaling"]
B --> C["Molecular cascade"]
C --> D["Cellular dysfunction"]
D --> E["Neuronal death"]
B --> F["Inflammatory response"]
F --> D
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
class B mechanism
class E disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning pi3k-akt-signaling in their description or question text
No additional research found