Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about senescence-SASP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | causes | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TBK1 Loss Drives Microglial Senescence-SASP to Generate MMP- | 0.499 | als | What are the mechanisms by which microgl |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 12 hypotheses Top: 0.878
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology a [PMID:36201573] | Unknown | Science | 2022 | 0 |
| Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP- [PMID:30458231] | Unknown | Neurobiology of disease | 2019 | 0 |
| TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and i [PMID:30146158] | Xu D, Jin T, Zhu H, Chen H, Ofengeim D, | Cell | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.33 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 6 · Score: 0.75 · 2026-04-26
Hypotheses and analyses mentioning senescence-SASP in their description or question text
No additional research found