Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about shy-drager-syndrome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| 1960 | Milton Shy and Glenda Drager described a syndrome of autonomic failure with parkinsonism[@shy1960a] |
| 1969 | The term "Shy-Drager syndrome" came into common use following detailed clinical descriptions[@bannister1972] |
| 1989 | Multiple system atrophy (MSA) was proposed as an umbrella term encompassing Shy-Drager syndrome, striatonigral degeneration, and olivopontocerebellar atrophy[@graham1989] |
| 1998 | Discovery of α-synuclein in glial cytoplasmic inclusions established the proteinaceous basis of MSA[@spillantini1997] |
| 2008 | Second consensus criteria for MSA established modern diagnostic framework[@gilman2008] |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
shy_drager_syndrome["<b>shy-drager-syndrome</b>"]
info["No connections yet"]
shy_drager_syndrome -.-> info
style shy_drager_syndrome fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7
style info fill:#2a2a2a,stroke:#666,stroke-dasharray:5,color:#999| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity