sod1-mutations-als

Understanding Entity Pages

This page aggregates everything SciDEX knows about sod1-mutations-als: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    SOD1["SOD1"]
    EIF2AK2["EIF2AK2"]
    SOD1 -->|"regulates"| EIF2AK2
    CX3CR1["CX3CR1"]
    SOD1 -->|"associated_with"| CX3CR1
    TBK1["TBK1"]
    SOD1 -->|"therapeutic_target"| TBK1
    NQO1["NQO1"]
    SOD1 -->|"associated_with"| NQO1
    Spinal_Cord["Spinal Cord"]
    SOD1 -->|"expressed_in"| Spinal_Cord
    ATP5A1["ATP5A1"]
    SOD1 -->|"interacts_with"| ATP5A1
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    SOD1 -->|"contributes_to"| AMYOTROPHIC_LATERAL_SCLEROSIS
    ALS["ALS"]
    SOD1 -->|"treats"| ALS
    GAIN["GAIN"]
    SOD1 -->|"activates"| GAIN
    Myelination["Myelination"]
    SOD1 -->|"contributes_to"| Myelination
    LYSOSOME["LYSOSOME"]
    SOD1 -->|"mediates"| LYSOSOME
    GFAP["GFAP"]
    SOD1 -->|"metabolizes"| GFAP
    style SOD1 fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style EIF2AK2 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style CX3CR1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style TBK1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style NQO1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Spinal_Cord fill:#0d3b54,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ATP5A1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style AMYOTROPHIC_LATERAL_SCLEROSIS fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style GAIN fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Myelination fill:#1b5e20,stroke:#333,stroke-width:1px,color:#e0e0e0
    style LYSOSOME fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style GFAP fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0