Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about synaptic vulnerability: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE ε4 | causes | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| APOE4-microglial complement signaling causes cholinergic-enr | 0.630 | neurodegeneration | What determines the temporal sequence of |
| Synaptic Vulnerability Window Temporal Targeting: Transient | 0.536 | synaptic biology | Does SPP1-mediated synaptic engulfment r |
| TREM2-Mediated Spatial Redistribution of Complement Regulato | 0.504 | synaptic biology | What determines the selectivity of compl |
| Astrocytic Complement Regulator Secretion Modulates Synaptic | 0.499 | synaptic biology | What determines the selectivity of compl |
| Complement Cascade Activation Bridges Microglial OxPC Sensin | 0.419 | neuroinflammation | What molecular mechanisms enable microgl |
| Astrocytic Complement Regulator Release Modulates Synaptic V | 0.380 | synaptic biology | What determines the selectivity of compl |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 3 hypotheses Top: 0.877
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024] | De Schepper S, Ge JZ, Sierksma A, Crowle | Nat Neurosci | 2023 | 2 |
| A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of dise [PMID:35953545] | ["Dr\u00e4ger Nina M", "Sattler Sydney M | Nature neuroscience | 2022 | 0 |
| Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-i [PMID:36076283] | Shi H, Yin Z, Koronyo Y, Fuchs DT, Sheyn | Acta neuropathologica communic | 2022 | 0 |
| Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alz [PMID:32579671] | Wang S, Mustafa M, Yuede CM, Salazar SV, | The Journal of experimental me | 2020 | 0 |
| Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alz [PMID:32579671] | Wang S, Mustafa M, Yuede CM, Salazar SV, | J Exp Med | 2020 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 0 · Score: 0.66 · 2026-04-21
closed · Rounds: 0 · Score: 0.64 · 2026-04-21
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
Hypotheses and analyses mentioning synaptic vulnerability in their description or question text