Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREM2 Protein: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Triggering receptor expressed on myeloid cells 2 (TREM2) is a type I transmembrane receptor of the immunoglobulin superfamily expressed predominantly on microglia. It signals through the adaptor TYROBP/DAP12 via immunoreceptor tyrosine-based activation motifs (ITAMs). TREM2 regulates microglial survival, proliferation, phagocytosis, and lipid sensing. Loss-of-function variants (R47H, R62H) increase Alzheimer's disease risk by 2-4 fold.
Ontology: MESH:D000072658 · Q9NZC2
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| Gene Symbol | triggering receptor expressed on myeloid cells 2 |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TREM2 Protein in their description or question text
No additional research found