Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ubiquitylation-dependent stability: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| UBQLN2 mutations | causes | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ubiquitylation-dependent turnover is the actionable driver i | 0.344 | neurodegeneration | How do ALS-linked UBQLN2 mutations affec |
| K48/K63 ubiquitin chain balance separates causal from compen | 0.335 | neurodegeneration | How do ALS-linked UBQLN2 mutations affec |
| proteasome shuttle failure defines the therapeutic window fo | 0.327 | neurodegeneration | How do ALS-linked UBQLN2 mutations affec |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.344
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217] | Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba | Autophagy | 2023 | 3 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| The genetics of amyotrophic lateral sclerosis. [PMID:38967083] | Nijs M, Van Damme P | Curr Opin Neurol | 2024 | 1 |
| Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal [PMID:41498748] | Unknown | The Journal of cell biology | 2026 | 0 |
| Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal [PMID:41498748] | Byrd, Marmorale, Marcinowski, Dykstra, A | The Journal of cell biology | 2026 | 0 |
| Carnitine Shuttle and Ferroptosis in Cancer. [PMID:40867868] | Kim YA, Lee Y, Kim MS | Antioxidants (Basel) | 2025 | 0 |
| Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy [PMID:38056575] | Wu S, Zhou Y, Liang J | Free Radic Biol Med | 2024 | 0 |
| Ripks and Neuroinflammation. [PMID:38349514] | Xu Y, Lin F, Liao G, Sun J, Chen W, Zhan | Molecular neurobiology | 2024 | 0 |
| The genetics of amyotrophic lateral sclerosis. [PMID:38967083] | Nijs M, Van Damme P | Curr Opin Neurol | 2024 | 0 |
| Endogenous retroviruses are dysregulated in ALS. [PMID:38989463] | Pasternack, Doucet-O'Hare, Johnson, Paul | iScience | 2024 | 0 |
| Common Driver Mutations in AML: Biological Impact, Clinical Considerations, and [PMID:39195279] | Nong T, Mehra S, Taylor J | Cells | 2024 | 0 |
| Endogenous retroviruses are dysregulated in ALS. [PMID:38989463] | Unknown | iScience | 2024 | 0 |
| Ripks and Neuroinflammation. [PMID:38349514] | Xu Y, Lin F, Liao G, Sun J, Chen W, Zhan | Molecular neurobiology | 2024 | 0 |
| Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217] | Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba | Autophagy | 2023 | 0 |
| Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport [PMID:36821445] | McGoldrick, Lau, You, Durcan, Robertson | Cell reports | 2023 | 0 |
| Targeted therapy for lung cancer: Beyond EGFR and ALK. [PMID:37073562] | Herrera-Juárez M, Serrano-Gómez C, Bote- | Cancer | 2023 | 0 |
| Lipocalin 2 regulates mitochondrial phospholipidome remodeling, dynamics, and fu [PMID:37872178] | Su H, Guo H, Qiu X | Nat Commun | 2023 | 0 |
| Listerin promotes cGAS protein degradation through the ESCRT pathway to negative [PMID:38109536] | Qin, Cai, Cao, Bai, Yuan et al. | Proceedings of the National Ac | 2023 | 0 |
| Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport [PMID:36821445] | Unknown | Cell reports | 2023 | 0 |
| Listerin promotes cGAS protein degradation through the ESCRT pathway to negative [PMID:38109536] | Unknown | Proceedings of the National Ac | 2023 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
Hypotheses and analyses mentioning ubiquitylation-dependent stability in their description or question text
No additional research found