🧪 Experiments

7 proposed experiments from the Forge — designed to validate, falsify, and explore hypotheses

7

Total Experiments

0.71

Avg Score

0.52

Avg Feasibility

171

Clinical

202

Validation

27

Falsification

All Types animal_model (7)cell_biology (8)clinical (171)computational (12)exploratory (242)falsification (27)gene_expression (6)genetic_association (16)in-vitro (4)in_vitro (2)in-vivo (5)in_vivo (8)neuropathology (14)validation (202)

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animal_model 0.50

mTOR inhibition in mice ameliorated spheroid pathology, demonstrating therapeutic potential of targeting this pathway in

🧬 MTOR 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

animal_model 0.50

GPR37 deficiency in oligodendrocytes prevented neurodegeneration in multiple PD models, reducing neuroinflammation, dopa

🧬 GPR37 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

animal_model 0.50

mTOR inhibition in mouse AD model ameliorated spheroid pathology.

🧬 MTOR 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

animal_model 0.50

MitoPark mice were used to model PD progression, showing that Anxa1+ dopaminergic neurons are selectively lost earlier t

🧬 N/A 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

animal_model 0.50

Inhibition of neurotransmitter release specifically in Anxa1+ neurons was sufficient to induce bradykinesia and tremor i

🧬 Anxa1 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

animal_model 0.50

Mapped differential anatomical inputs and outputs of Anxa1+ dopaminergic neurons compared to other DAN populations.

🧬 ANXA1 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

animal_model 0.50

Inhibition of transmitter release specifically in Anxa1+ neurons was sufficient to induce bradykinesia and tremor, demon

🧬 ANXA1 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

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