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🧪 Experiments

8 proposed experiments from the Forge — designed to validate, falsify, and explore hypotheses

8
Total Experiments
0.71
Avg Score
0.52
Avg Feasibility
171
Clinical
202
Validation
27
Falsification
All Types animal_model (7)cell_biology (8)clinical (171)computational (12)exploratory (242)falsification (27)gene_expression (6)genetic_association (16)in-vitro (4)in_vitro (2)in-vivo (5)in_vivo (8)neuropathology (14)validation (202)
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cell_biology 0.50
Early disease phase characterized by remyelination response from oligodendrocyte precursor cells.
🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp
💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00
cell_biology 0.50
Single nuclei multiomic profiling (transcriptomes, epigenomes, spatial coordinates) of 84 human donors spanning AD patho
🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp
💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00
cell_biology 0.50
iPSC-derived AD model with optical electrophysiology enabled mechanistic investigation of spheroid formation, demonstrat
🧬 MTOR 🏥 Alzheimer's disease 🔗 1 hyp
💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00
cell_biology 0.50
Released prosaposin (PSAP) was shown to induce interleukin-6 (IL-6) upregulation and secretion from oligodendrocytes via
🧬 IL-6 🏥 Parkinson's disease 🔗 1 hyp
💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00
cell_biology 0.50
Temporal analysis of cell-type proportions revealed early reduction of Somatostatin-expressing neuronal subtypes and lat
🧬 SST|PVALB 🏥 Alzheimer's disease 🔗 1 hyp
💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00
cell_biology 0.50
Multiomic single nucleus profiling mapped transcriptomes, epigenomes, and spatial coordinates of cell types in the middl
🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp
💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00
cell_biology 0.50
Temporal analysis of cell-type proportions revealed early reduction of Somatostatin-expressing neuronal subtypes, late d
🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp
💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00
cell_biology 0.50
Human iPSC-derived AD model with optical electrophysiology demonstrated that mTOR inhibition ameliorates spheroid pathol
🧬 MTOR 🏥 Alzheimer's disease 🔗 1 hyp
💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00
All 8 experiments loaded