🧪 Experiments

12 proposed experiments from the Forge — designed to validate, falsify, and explore hypotheses

12

Total Experiments

0.71

Avg Score

0.52

Avg Feasibility

171

Clinical

202

Validation

27

Falsification

All Types animal_model (7)cell_biology (8)clinical (171)computational (12)exploratory (242)falsification (27)gene_expression (6)genetic_association (16)in-vitro (4)in_vitro (2)in-vivo (5)in_vivo (8)neuropathology (14)validation (202)

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computational 0.85

Multi-Biomarker Composite for Early Detection of Neurodegenerative Disease

🧬 N/A 🏥 Alzheimer disease

💰 $28,000 ⏱ 6mo ✅ 0.78 ✨ 0.80

Expected: Composite biomarker index achieves AUC > 0.90 for AD vs. controls (vs. <0.80 for amyloid PET alone) ...

computational 0.50

Nanoscale imaging in aging macaques used to investigate earliest pathological stages, where initial phosphorylation even

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

computational 0.50

Proximity labeling approach combined with proteomics identified subcellular molecular architecture of spheroids in human

🧬 MTOR 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

computational 0.50

12 newly identified AD-associated genes show prior evidence linking them to neurofibrillary tangles or phosphorylated ta

🧬 PCDH9, NRG3, ROR1, LINGO2, SMYD3, LRRC7 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

computational 0.50

Proximity labeling proteomics in mouse brains revealed similar spheroid abnormalities in protein turnover, cytoskeleton

🧬 MTOR 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

computational 0.50

A subset of donors exhibited particularly severe cellular and molecular phenotypes that correlated with steeper cognitiv

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

computational 0.50

This abstract describes SEA-AD (Seattle Alzheimer's Disease Brain Cell Atlas), a multimodal open data resource integrati

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

computational 0.50

Proximity labeling proteomics of axonal spheroids in human postmortem AD brains identified abnormalities in protein turn

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

computational 0.50

Proximity labeling proteomics of axonal spheroids in mouse AD model brains identified abnormalities in protein turnover,

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

computational 0.50

Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early phase characterized

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

computational 0.50

Chromatin accessibility profiling (ATAC-seq) revealed unique chromatin signature in depleted CD83+ microglia population

🧬 HIF1A 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

computational 0.50

Multimodal cell atlas analysis of 84 human AD donor brains identified two disease phases: an early phase with inflammato

🧬 N/A 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

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