🧪 Experiments

genetic_association 0.50

Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of somatic single-nucl

🧬 cancer driver genes; clonal hematopoiesis genes (CSF1R) 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in cancer driver genes in

🧬 cancer driver genes; CSF1R; clonal hematopoiesis genes 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

GWANN identified 18 genes associated with family history of AD in UK Biobank, including 6 previously known AD genes (APO

🧬 APOE, BIN1, SORL1, ADAM10, APH1B, SPI1, PCDH9, NRG3, ROR1, LINGO2, SMYD3, LRRC7 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Individuals with SNCA pathogenic variants reported painful dystonia, lower extremity pain, dorsal pain, and upper back p

🧬 SNCA 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Painful lower limb dystonia and lower back pain are prominent symptoms in PRKN carriers.

🧬 PRKN 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Continual correlation noted between LRRK2 mutations and pain emergence, though conflicting research outcomes pose challe

🧬 LRRK2 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

PINK1 mutation carriers frequently report experiencing pain.

🧬 PINK1 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Pain has been frequently reported as an initial symptom and the most troublesome one in GBA1-PD patients compared to tho

🧬 GBA1 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Evidence regarding pain in ATP13A2 pathogenic variants is limited and insufficient.

🧬 ATP13A2 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Evidence regarding pain in VPS35 pathogenic variants is limited and insufficient.

🧬 VPS35 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Evidence regarding pain in DNAJC6 pathogenic variants is limited and insufficient.

🧬 DNAJC6 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Evidence regarding pain in FBXO7 pathogenic variants is limited and insufficient.

🧬 FBXO7 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Evidence regarding pain in SYNJ1 pathogenic variants is limited and insufficient.

🧬 SYNJ1 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Participants carrying the APOE epsilon 4 allele showed more rapid biomarker changes (decreasing Aβ42:Aβ40 and increasing

🧬 APOE 🏥 Alzheimer's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Identification of a vulnerable subtype of dopaminergic neurons co-expressing Sox6 and Anxa1 that shows selective vulnera

🧬 Sox6, Anxa1 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00

genetic_association 0.50

Generated a knock-in Cre mouse line for Anxa1+ dopaminergic neurons to enable targeted manipulation of this population.

🧬 ANXA1 🏥 Parkinson's disease 🔗 1 hyp

💰 N/A ⏱ N/A ✅ 0.00 ✨ 0.00