PERK Inhibitor GSK2606414 + GADD34 Mimetic Sephin1 Rescues eIF2alpha Stalling in ALS iPSC Motor Neurons
🧬 EIF2S1, EIF2AK3/PERK, PPP1R15B, EIF2B
🏥 ALS / FTD
🔗 1 hyp
💰 $67,000
⏱ 16mo
✅ 0.85
✨ 0.76
Differentiate iPSC-MNs (35-day protocol; ISL1+/HB9+ purity >=85%). 2. Treat at day 35 with GSK2606414 (200 nM) +/- Sephi...
Expected: Combined treatment will normalise p-eIF2alpha by >=50%, restore polysome/monosome ratio by >=30%, re...
TREM2 R47H iPSC Co-culture Screen for A1 Astrocyte Polarisation Rescue Compounds
🧬 TREM2
🏥 Alzheimer's disease
🔗 1 hyp
💰 $52,000
⏱ 12mo
✅ 0.75
✨ 0.76
Differentiate iPSC lines (3 R47H donors + isogenic WT) to astrocytes (42-day protocol) and microglia (28-day protocol). ...
Expected: TREM2 R47H co-cultures will show >=2x increase in C3/LCN2 vs isogenic WT. >=3 compounds will rescue ...