nSMase2 Inhibitor DPTIP Rescues Synaptic Density in APPswe/PS1deltaE9 Mice
🧬 SMPD3
🏥 Alzheimer's disease
🔗 1 hyp
💰 $62,000
⏱ 14mo
✅ 0.74
✨ 0.80
Treat APP/PS1 mice with DPTIP (10 mg/kg i.p., daily) or vehicle for 12 weeks (6-9 months). 2. Weekly body weight, open f...
Expected: DPTIP will reduce ceramide Cer16:0 by >=60%, cut exosome secretion by >=40%, restore PSD-95 to withi...
TREM2 Agonist Antibody Rescue of Astrocyte-Microglia Signalling in 5xFAD Mice
🧬 TREM2
🏥 Alzheimer's disease
🔗 1 hyp
💰 $85,000
⏱ 18mo
✅ 0.72
✨ 0.78
Breed 5xFAD hemizygous x C57BL/6J; genotype at P21. 2. Randomise to 4 groups at 3 months (n=15/group, sex-balanced). 3. ...
Expected: AL002c-analogue will suppress astrocyte A1 conversion by >=40% (C3, Lcn2), shift microglia toward DA...
Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State in LPS-Challenged and 3xTg-AD Mice
🧬 MIR155
🏥 neurodegeneration
🔗 1 hyp
💰 $58,000
⏱ 14mo
✅ 0.65
✨ 0.82
Synthesise LNA-155 (5-T+G+T+A+G+C+A+T+T+A+A-3) or scramble-LNA. 2. Intrathecal implant osmotic pump (2 ug/day, 28-day re...
Expected: LNA-155 will reduce microglial miR-155 >=60%, suppress IFN-gamma/IL-6 in CSF >=40%, increase SHIP1 p...
40 Hz Auditory + Visual Gamma Stimulation Reduces Amyloid and Entrains LFP in 5xFAD Mice
🧬 N/A
🏥 Alzheimer's disease
🔗 1 hyp
💰 $72,000
⏱ 14mo
✅ 0.68
✨ 0.79
Implant tetrode LFP arrays in CA1 of 5xFAD and WT mice at 4 months. 2. Recovery 1 week; then 4 treatment groups: WT-sham...
Expected: Combined stimulation will entrain CA1 gamma >=2x baseline, reduce soluble Abeta42 >=40%, activate mi...
Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat Cardiac-Arrest Model
🧬 GPX4
🏥 post-cardiac-arrest neurodegeneration
🔗 1 hyp
💰 $48,000
⏱ 12mo
✅ 0.72
✨ 0.74
Asphyxial CA: 6-min KCl arrest + CPR in adult SD rats. 2. Groups: sham, CA-vehicle, CA-DFO (100 mg/kg IV at ROSC), CA...
Expected: DFO+SFN will blunt the iron surge (CSF ferritin <=50% of vehicle), maintain GPX4 activity, reduce MR...
Closed-loop tFUS Enhances Glymphatic Clearance and Restores CA1 PV Interneuron Gamma in APP/PS1 Mice
🧬 PVALB
🏥 Alzheimer's disease
🔗 1 hyp
💰 $125,000
⏱ 20mo
✅ 0.55
✨ 0.87
APP/PS1 mice, 8 months, MRI-guided tFUS targeting dorsal CA1. 2. Closed-loop: slow-oscillation (0.5-1 Hz) detection -> t...
Expected: tFUS will increase glymphatic influx 2x (gadolinium signal), reduce PV-soma-adjacent Abeta >=35%, re...
Conditional TYROBP Knockdown in Early-Stage 5xFAD Mice Using CRISPRi-AAV9
🧬 TYROBP
🏥 Alzheimer's disease
🔗 1 hyp
💰 $95,000
⏱ 20mo
✅ 0.55
✨ 0.84
Construct AAV9-flex-dCas9-KRAB with 3 sgRNAs targeting TYROBP exon 2. 2. ICV injection at P60 (2 uL, 5e12 vg/mL) in 5xFA...
Expected: CRISPRi will reduce TYROBP 50-70%, shift microglia away from DAM-high inflammatory states, preserve ...
tFUS Targeting EC-II SST Interneurons Restores Hippocampal-Prefrontal Gamma Sync in hAPP-J20 Mice
🧬 SST
🏥 Alzheimer's disease
🔗 1 hyp
💰 $110,000
⏱ 22mo
✅ 0.48
✨ 0.88
Implant LFP/unit recording arrays in EC-II, CA1, mPFC at 3 months hAPP-J20. 2. Closed-loop tFUS system: real-time theta ...
Expected: Closed-loop tFUS will increase gamma coherence >=2x, drive SST interneuron firing phase-locked to th...