The debate focused on therapeutic targets but did not address how to identify patients in the optimal treatment window. Without reliable biomarkers for microglial priming, clinical translation of these hypotheses remains problematic. Source: Debate session sess_SDA-2026-04-04-gap-20260404-microglial-priming-early-ad (Analysis: SDA-2026-04-04-gap-20260404-microglial-priming-early-ad)
Landscape Summary: What biomarkers can reliably detect microglial priming states in living patients before neurodegeneration? is a 0.88 priority gap in biomarkers. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.
Colonna, Sevlever, et al. (TREM2 biology)
What biomarkers can reliably detect microglial priming states in living patients before neurodegeneration? — INVOKE-2 (completed)
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