The debate mentioned tau PTM targeting but did not identify which modifications are both disease-specific and accessible for therapeutic intervention. This knowledge gap limits the development of PTM-based selective targeting approaches. Source: Debate session sess_SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd (Analysis: SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd)
Landscape Summary: Which specific post-translational modifications on pathological tau create druggable epitopes absent in physiological tau? is a 0.79 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.
Colonna, Sevlever, et al. (TREM2 biology)
Which specific post-translational modifications on pathological tau create druggable epitopes absent in physiological tau? — INVOKE-2 (completed)
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