The finding that trehalase-resistant analogs and other disaccharides mimic trehalose's effects suggests a common mechanism independent of trehalose-specific pathways. The shared molecular target or mechanism among these diverse compounds remains unidentified, limiting rational drug design. Gap type: unexplained_observation Source paper: Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration. (2019, Autophagy, PMID:30335591)
Landscape Summary: Why do structurally diverse sugars (trehalose, melibiose, lactulose) produce identical autophagy effects? is a 0.79 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.
Colonna, Sevlever, et al. (TREM2 biology)
Why do structurally diverse sugars (trehalose, melibiose, lactulose) produce identical autophagy effects? — INVOKE-2 (completed)
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