While the abstract establishes that intercellular transmission occurs for various proteins (tau, α-synuclein, TDP-43), the mechanisms governing transmission selectivity and efficiency remain poorly understood. This gap impedes development of transmission-blocking therapeutics. Gap type: unexplained_observation Source paper: Protein transmission in neurodegenerative disease. (2020, Nat Rev Neurol, PMID:32203399)
Landscape Summary: What determines the selectivity and efficiency of intercellular transmission pathways for different misfolded proteins? is a 0.74 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.
Colonna, Sevlever, et al. (TREM2 biology)
What determines the selectivity and efficiency of intercellular transmission pathways for different misfolded proteins? — INVOKE-2 (completed)
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