The abstract acknowledges that host cells influence seed properties, but the specific cellular factors and mechanisms involved are not well understood. This knowledge gap limits our ability to predict disease progression and develop cell-targeted therapies. Gap type: open_question Source paper: Protein transmission in neurodegenerative disease. (2020, Nat Rev Neurol, PMID:32203399)
Landscape Summary: How do host cell factors influence the conformation and propagation properties of transmitted pathological seeds? is a 0.76 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.
Colonna, Sevlever, et al. (TREM2 biology)
How do host cell factors influence the conformation and propagation properties of transmitted pathological seeds? — INVOKE-2 (completed)
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