While the abstract mentions identifying subcellular roles of protein interactions, the mechanistic principles governing how interaction networks specify subcellular function remain unclear. This knowledge gap limits our ability to predict how disease mutations disrupt cellular compartmentalization in neurons. Gap type: open_question Source paper: A reference map of the human binary protein interactome. (2020, Nature, PMID:32296183)
Landscape Summary: How do protein-protein interactions determine subcellular localization and function specificity? is a 0.77 priority gap in synaptic-biology. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.
Colonna, Sevlever, et al. (TREM2 biology)
How do protein-protein interactions determine subcellular localization and function specificity? — INVOKE-2 (completed)
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