The abstract identifies somatic mosaicism as a potential mechanism but doesn't explain how it contributes to disease development. This knowledge gap limits understanding of disease penetrance and could impact genetic counseling and treatment strategies. Gap type: open_question Source paper: EphrinB2-EphB4-RASA1 Signaling in Human Cerebrovascular Development and Disease. (2019, Trends Mol Med, PMID:30819650)
Landscape Summary: How does somatic mosaicism contribute to ephrinB2-EphB4-RASA1-related cerebrovascular disease pathogenesis? is a 0.74 priority gap in cerebrovascular-development. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How does somatic mosaicism contribute to ephrinB2-EphB4-RASA1-related cerebrovascular disease pathogenesis? — INVOKE-2 (completed)
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