The discordance between Mendelian randomization associations and colocalization evidence for most proteins suggests potential confounding or indirect effects. This methodological gap limits confidence in causal inference for neurological complications of diabetes. Gap type: unexplained_observation Source paper: Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses. (2023, Cell Rep Med, PMID:37652020)
Landscape Summary: Why do only 11 of 47 diabetes-associated proteins show strong colocalization support? is a 0.73 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Why do only 11 of 47 diabetes-associated proteins show strong colocalization support? — INVOKE-2 (completed)
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