While the abstract discusses combination therapies for cancer, it's unclear which PRMT pathways might be synergistically targeted in neurological conditions. This represents a significant translational gap given PRMTs' role in neuronal function. Gap type: open_question Source paper: Protein arginine methylation: from enigmatic functions to therapeutic targeting. (2021, Nat Rev Drug Discov, PMID:33742187)
Landscape Summary: Which PRMT pathways could be synergistically targeted for neurological diseases beyond cancer? is a 0.75 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Which PRMT pathways could be synergistically targeted for neurological diseases beyond cancer? — INVOKE-2 (completed)
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