The abstract shows that removing canonical E2F activators increases genome ploidy in endocycling cells, yet these same factors coordinate G2/M programs critical for mitosis. This paradoxical relationship between mitotic promotion and endocycle regulation lacks mechanistic explanation. Gap type: contradiction Source paper: Canonical and atypical E2Fs regulate the mammalian endocycle. (2013, Nature cell biology, PMID:23064266)
Landscape Summary: How do canonical E2Fs promote mitosis while simultaneously augmenting endocycle ploidy when ablated? is a 0.79 priority gap in cell-biology. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How do canonical E2Fs promote mitosis while simultaneously augmenting endocycle ploidy when ablated? — INVOKE-2 (completed)
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