The authors discovered that phagocytosing microglia and macrophages can be identified by their ingestion and perinuclear import of myelin transcripts, but the cellular machinery and functional consequences of this transcript import process are not explained. This novel observation could reveal new aspects of glial-myelin interactions in MS pathology. Gap type: unexplained_observation Source paper: Neuronal vulnerability and multilineage diversity in multiple sclerosis. (2019, Nature, PMID:31316211)
Landscape Summary: How do phagocytosing microglia/macrophages import and process ingested myelin transcripts perinuclearly? is a 0.76 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How do phagocytosing microglia/macrophages import and process ingested myelin transcripts perinuclearly? — INVOKE-2 (completed)
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