The abstract mentions ZBTB7C may modulate ischemic response via both neuronal apoptosis and dynamic collateralization, but doesn't clarify which mechanism predominates or how they interact. This distinction is crucial for understanding therapeutic targets. Gap type: unexplained_observation Source paper: Integrative Mouse and Human Studies Implicate ANGPT1 and ZBTB7C as Susceptibility Genes to Ischemic Injury. (None, None, PMID:26542693)
Landscape Summary: What is the relative contribution of ZBTB7C's effects on neuronal apoptosis versus collateralization? is a 0.79 priority gap in cerebrovascular. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What is the relative contribution of ZBTB7C's effects on neuronal apoptosis versus collateralization? — INVOKE-2 (completed)
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