Combined biomarker models outperformed single-biomarker approaches, but the study doesn't explain what distinct pathological processes each biomarker captures. Understanding these complementary mechanisms could reveal new therapeutic targets and optimize biomarker strategies for preclinical AD. Gap type: unexplained_observation Source paper: Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials. (2025, Nature aging, PMID:40155777)
Landscape Summary: What biological mechanisms account for the additional predictive value when combining plasma p-tau217 and tau-PET? is a 0.76 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What biological mechanisms account for the additional predictive value when combining plasma p-tau217 and tau-PET? — INVOKE-2 (completed)
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