While small GTPases are known to play essential roles in autophagy and lysosomal degradation of amyloid β, their comparable function in tau clearance is unclear. This represents a critical gap for understanding differential protein aggregate handling in AD. Gap type: open_question Source paper: The role of small GTPases in Alzheimer's disease tau pathologies. (2025, Frontiers in cellular neuroscience, PMID:41080460)
Landscape Summary: Do small GTPases regulate tau clearance pathways similarly to their established role in amyloid β degradation? is a 0.79 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Do small GTPases regulate tau clearance pathways similarly to their established role in amyloid β degradation? — INVOKE-2 (completed)
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