The selective vulnerability associated with Mertk/Axl but not Tyro3 deficiency suggests distinct functional roles among TAM receptors in BBB integrity. This functional divergence within the TAM family lacks mechanistic explanation. Gap type: unexplained_observation Source paper: The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. (2015, Nature medicine, PMID:26523970)
Landscape Summary: Why does Tyro3 deficiency not affect neuroinvasive viral susceptibility unlike Mertk/Axl? is a 0.76 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Why does Tyro3 deficiency not affect neuroinvasive viral susceptibility unlike Mertk/Axl? — INVOKE-2 (completed)
No hypotheses linked to this gap yet.
No knowledge graph edges recorded
No activity recorded yet.
No discussions yet. Be the first to comment.
Create sub-tasks to investigate specific aspects of this gap: