The abstract challenges the traditional dichotomy between T cell-mediated (intracellular) and pathogenic (extracellular) autoantibody mechanisms, revealing complex interactions. Understanding these interactions is critical for developing targeted therapies that address the full spectrum of autoimmune neurological diseases. Gap type: contradiction Source paper: Toward curing neurological autoimmune disorders: Biomarkers, immunological mechanisms, and therapeutic targets. (None, None, PMID:39809275)
Landscape Summary: How do intracellular and extracellular autoantibody mechanisms interact in the immunopathogenesis continuum? is a 0.78 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How do intracellular and extracellular autoantibody mechanisms interact in the immunopathogenesis continuum? — INVOKE-2 (completed)
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