While the study identifies two distinct atrophy classes in MCI and links them to microglia proteins, the upstream factors determining why some patients follow slow versus fast atrophy trajectories remain unknown. Understanding these drivers could enable early stratification. Gap type: unexplained_observation Source paper: Heterogeneity of cerebral atrophic rate in mild cognitive impairment and its interactive association with proteins related to microglia activity on longitudinal cognitive changes. (2024, Archives of gerontology and geriatrics, PMID:39079281)
Landscape Summary: What drives the heterogeneity in cerebral atrophic rates among MCI patients with similar clinical presentations? is a 0.82 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What drives the heterogeneity in cerebral atrophic rates among MCI patients with similar clinical presentations? — INVOKE-2 (completed)
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