The study shows CD40 accelerates cognitive decline in slow-atrophy MCI but AXL/TNF-R2 are protective in fast-atrophy MCI. The biological mechanisms underlying these context-dependent, opposing effects of microglia activity remain unexplained. Gap type: unexplained_observation Source paper: Heterogeneity of cerebral atrophic rate in mild cognitive impairment and its interactive association with proteins related to microglia activity on longitudinal cognitive changes. (2024, Archives of gerontology and geriatrics, PMID:39079281)
Landscape Summary: What mechanisms explain why microglia proteins have opposite cognitive effects in slow vs fast atrophy MCI? is a 0.85 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What mechanisms explain why microglia proteins have opposite cognitive effects in slow vs fast atrophy MCI? — INVOKE-2 (completed)
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