The abstract indicates gene suppression has shown promise in Huntington's disease and other inherited neurodegeneration but acknowledges the challenge of applying these to other proteinopathy dementias. The mechanistic and targeting differences between monogenic and complex diseases remain unresolved. Gap type: open_question Source paper: Gene suppression approaches to neurodegeneration. (2017, Alzheimer's research & therapy, PMID:28982376)
Landscape Summary: How can gene suppression approaches be effectively translated from monogenic diseases to complex proteinopathy-associated dementias? is a 0.76 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How can gene suppression approaches be effectively translated from monogenic diseases to complex proteinopathy-associated dementias? — INVOKE-2 (completed)
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