While PPI analysis identifies calcium channel subunits as central hubs connecting male and female pathological networks, the specific molecular interactions and signaling cascades remain undefined. This mechanistic gap limits understanding of how calcium channel modulation achieves therapeutic effects. Gap type: unexplained_observation Source paper: Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: sexually dimorphic regulatory networks linking calcium channels to the complement cascade. (2026, Frontiers in immunology, PMID:41853292)
Landscape Summary: How do voltage-gated calcium channels mechanistically link sex-specific pathological modules in trigeminal neuralgia? is a 0.82 priority gap in neuropathic-pain. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How do voltage-gated calcium channels mechanistically link sex-specific pathological modules in trigeminal neuralgia? — INVOKE-2 (completed)
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