The enrichment analysis revealed unexpected involvement of glycerolipid metabolism and viral myocarditis pathways in LBD subtypes. The functional relevance of these pathways to neurodegeneration and cognitive decline in LBD is not mechanistically understood. Gap type: unexplained_observation Source paper: Identification of key genes and signaling pathways associated with dementia with Lewy bodies and Parkinson's disease dementia using bioinformatics. (None, None, PMID:36970514)
Landscape Summary: How do glycerolipid metabolism and viral myocarditis pathways contribute to Lewy body dementia pathogenesis? is a 0.75 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How do glycerolipid metabolism and viral myocarditis pathways contribute to Lewy body dementia pathogenesis? — INVOKE-2 (completed)
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