The authors explicitly identify a substantial translational gap in adapting emerging therapies to the aged brain, citing differences in immune responses and neurovascular integrity. This represents a critical barrier to developing effective stroke treatments for the most vulnerable population. Gap type: open_question Source paper: The age-associated decline in neuroplasticity and its implications for post-stroke recovery in animal models of cerebral ischemia: The therapeutic role of extracellular vesicles. (2026, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, PMID:40770923)
Landscape Summary: How can therapeutic strategies be adapted to overcome age-related differences in immune responses and neurovascular integrity post-stroke? is a 0.82 priority gap in cerebrovascular. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How can therapeutic strategies be adapted to overcome age-related differences in immune responses and neurovascular integrity post-stroke? — INVOKE-2 (completed)
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