The abstract notes that Lewy pathology in LRRK2-PD correlates with cognitive deficits, anxiety, and orthostatic hypotension, but not with the classic motor symptoms of PD. This selective association suggests distinct pathogenic mechanisms that remain unexplored. Gap type: unexplained_observation Source paper: Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein. (None, None, PMID:34749824)
Landscape Summary: Why does Lewy pathology in LRRK2-PD specifically associate with non-motor symptoms rather than motor symptoms? is a 0.77 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Why does Lewy pathology in LRRK2-PD specifically associate with non-motor symptoms rather than motor symptoms? — INVOKE-2 (completed)
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