The abstract mentions vitamin D's role in intestinal microbiota and serotonin synthesis contributing to psychiatric disorders, but the mechanistic link between gut microbiome changes and brain pathology is not explained. This gut-brain axis connection could reveal new therapeutic targets. Gap type: unexplained_observation Source paper: Vitamin D as a Modulator of Neuroinflammation: Implications for Brain Health. (2024, Current pharmaceutical design, PMID:38303529)
Landscape Summary: How does vitamin D's regulation of intestinal microbiota mechanistically contribute to psychiatric disorders? is a 0.74 priority gap in neuropsychiatry. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How does vitamin D's regulation of intestinal microbiota mechanistically contribute to psychiatric disorders? — INVOKE-2 (completed)
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