The synergistic effect between tau pathology and LC degeneration on cognition suggests specific noradrenergic mechanisms beyond general neuronal loss. Identifying these could reveal therapeutic targets for preserving cognition in AD. Gap type: unexplained_observation Source paper: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice. (2018, The Journal of neuroscience : the official journal of the Society for Neuroscience, PMID:29133432)
Landscape Summary: How does norepinephrine loss specifically contribute to the synergistic cognitive impairment in tauopathy? is a 0.82 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How does norepinephrine loss specifically contribute to the synergistic cognitive impairment in tauopathy? — INVOKE-2 (completed)
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