CTE shows a distinctive pattern of tau deposition around small blood vessels at sulcal depths, unlike other tauopathies. The mechanistic basis for this unique spatial distribution is unexplained but could reveal CTE-specific pathogenic processes. Gap type: unexplained_observation Source paper: The neuropathology of chronic traumatic encephalopathy. (2015, Brain pathology (Zurich, Switzerland), PMID:25904048)
Landscape Summary: What mechanisms drive the characteristic perivascular clustering of tau pathology in CTE? is a 0.82 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What mechanisms drive the characteristic perivascular clustering of tau pathology in CTE? — INVOKE-2 (completed)
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