The TRUE-MOGAD score uses clinical variables to distinguish true from false positives, but the biological basis for why certain clinical presentations correlate with authentic MOG antibody pathogenicity remains unexplained. This knowledge gap limits understanding of MOGAD pathophysiology. Gap type: unexplained_observation Source paper: TRUE-MOGAD Score: A Novel Scoring System to Identify MOGAD Among Positive MOG-IgG Test Results. (2026, Neurol Neuroimmunol Neuroinflamm, PMID:41921125)
Landscape Summary: How do clinical features mechanistically relate to true vs. false positive MOG-IgG results? is a 0.73 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How do clinical features mechanistically relate to true vs. false positive MOG-IgG results? — INVOKE-2 (completed)
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