While the Braak hypothesis describes prion-like spread of α-synuclein from gut to brain, the specific role of enteric glia in this propagation process remains mechanistically unclear. This knowledge gap limits understanding of early PD pathogenesis and potential intervention points. Gap type: unexplained_observation Source paper: Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogenesis. (2023, Ageing Res Rev, PMID:36455790)
Landscape Summary: How do enteric glia specifically contribute to α-synuclein propagation from gut to brain via the vagus nerve? is a 0.8 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How do enteric glia specifically contribute to α-synuclein propagation from gut to brain via the vagus nerve? — INVOKE-2 (completed)
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