The strict isoform pairing requirement demonstrated in HEK cells may not translate to the complex cellular environment of the brain. Validating these findings in vivo is critical for understanding natural disease progression and developing realistic therapeutic models. Gap type: open_question Source paper: Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. (2016, Proceedings of the National Academy of Sciences of the United States of America, PMID:27911827)
Landscape Summary: Do the isoform pairing requirements for tau prion propagation observed in cell culture reflect in vivo transmission mechanisms? is a 0.75 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Do the isoform pairing requirements for tau prion propagation observed in cell culture reflect in vivo transmission mechanisms? — INVOKE-2 (completed)
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