Both olfactory dysfunction and abnormal color vision strongly predicted conversion (HR 2.8 and 3.1 respectively), but the pathophysiological connections to alpha-synuclein pathology remain unclear. Elucidating these links could identify early intervention targets. Gap type: unexplained_observation Source paper: Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials. (2015, Neurology, PMID:25681454)
Landscape Summary: What mechanisms link olfactory loss and color vision deficits to synucleinopathy progression? is a 0.74 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What mechanisms link olfactory loss and color vision deficits to synucleinopathy progression? — INVOKE-2 (completed)
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