While 97% of CTE cases have RHI exposure, not all individuals with similar exposure develop the disease, suggesting unknown susceptibility factors. Identifying these factors could enable risk stratification and personalized prevention strategies. Gap type: unexplained_observation Source paper: Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts. (None, None, PMID:36759368)
Landscape Summary: What determines why only some individuals with RHI exposure develop CTE pathology? is a 0.76 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What determines why only some individuals with RHI exposure develop CTE pathology? — INVOKE-2 (completed)
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