Both calpain and proteasome activities are increased in the V144D mutant, but their individual contributions to microtubule-associated protein loss and transport defects are unclear. Defining these roles is essential for prioritizing therapeutic intervention strategies. Gap type: unexplained_observation Source paper: Calcium-Mediated Calpain Activation and Microtubule Dissociation in Cell Model of Hereditary Sensory Neuropathy Type-1 Expressing V144D (2022, DNA and cell biology, PMID:34986032)
Landscape Summary: What determines the relative contributions of calpain vs proteasome pathways to cytoskeletal degradation in HSN1A? is a 0.72 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What determines the relative contributions of calpain vs proteasome pathways to cytoskeletal degradation in HSN1A? — INVOKE-2 (completed)
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