The study shows calpain activation reduces MAP2 and tau specifically, but the mechanism of selective substrate targeting is not explained. This selectivity could reveal therapeutic targets to preserve essential cytoskeletal proteins while allowing beneficial protein turnover. Gap type: unexplained_observation Source paper: Calcium-Mediated Calpain Activation and Microtubule Dissociation in Cell Model of Hereditary Sensory Neuropathy Type-1 Expressing V144D (2022, DNA and cell biology, PMID:34986032)
Landscape Summary: How does calpain selectively target specific MAPs while sparing others in HSN1A pathogenesis? is a 0.75 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How does calpain selectively target specific MAPs while sparing others in HSN1A pathogenesis? — INVOKE-2 (completed)
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