The abstract suggests cell-autonomous treatments may be crucial for addressing epilepsy gene therapy challenges, but doesn't explain how to achieve cell-specific targeting given epilepsy's complex, multi-cellular pathogenic mechanisms. Gap type: open_question Source paper: Recent advances and current status of gene therapy for epilepsy. (2024, World journal of pediatrics : WJP, PMID:39395088)
Landscape Summary: How can cell-autonomous gene therapy treatments be designed to address epilepsy's complex pathogenic mechanisms? is a 0.72 priority gap in neurotherapeutics. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How can cell-autonomous gene therapy treatments be designed to address epilepsy's complex pathogenic mechanisms? — INVOKE-2 (completed)
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