The study shows elevated Aβ40:42 ratios in vessels with CAA, but extremely low ratios in apoE-deficient vessels without CAA. The mechanistic basis for this dramatic shift in peptide ratios and its relationship to vascular pathology is not explained. Gap type: unexplained_observation Source paper: Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. (2003, The Journal of neuroscience : the official journal of the Society for Neuroscience, PMID:12944519)
Landscape Summary: Why does the Aβ40:42 ratio differ dramatically between CAA-positive and apoE-deficient vessels? is a 0.82 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Why does the Aβ40:42 ratio differ dramatically between CAA-positive and apoE-deficient vessels? — INVOKE-2 (completed)
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