FUS Phase Separation Dominance in FTD-TDP: Aberrant Condensate Hijacking of RNA Processing Droplets
🧬 FUS
🏥 frontotemporal-dementia
📖 0🏛 1
✅ 0.00
✨ 0.70
💥 0.00
In ALS motor neurons, disease-modified RBM45 hijacks RNA processing condensates through altered LLPS behavior, displacing TDP-43 into pathological agg...
Microglial TBK1 Deficiency Triggers Senescence-Associated Secretory Phenotype in Frontotemporal Dementia
🧬 TBK1
🏥 frontotemporal-dementia
📖 5🏛 1
✅ 0.00
✨ 0.70
💥 0.00
Loss-of-function mutations in TBK1, a established risk factor for familial FTD, may trap microglia in a senescent, pro-inflammatory state characterize...
ISR/eIF2α~P Overflow Represses Synaptic Proteostasis in Cortical Neurons in TDP-43-Type Frontotemporal Dementia
🧬 TARDBP (TDP-43)
🏥 frontotemporal-dementia
📖 0🏛 1
✅ 0.00
✨ 0.70
💥 0.00
In ALS, chronic ISR activation creates an eIF2α~P state that represses axonal protein synthesis below synaptic maintenance thresholds, causing NMJ den...